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The three main forms of human estrogen are 190 : estrone (E1), which can be synthesized by fat cells and plays a larger physiological role after menopause estradiol (E2), which is the strongest estrogen and predominates in the reproductive years estriol (E3), which is sometimes described as a weak estrogen, and circulates at low levels during the reproductive life stage, except during pregnancy when the placenta produces large amounts Over the last few decades, there has been some debate regarding the relative strength of E1, E2, and E3, particularly as it relates to their inclusion in compounded systemic hormone replacement therapy formulations

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High folic acid may even exacerbate anemia and cognitive symptoms