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These monoclonal antibodies bind and inactivate circulating tumour necrosis factor (TNF) alpha, disrupting the inflammatory cascade with a more targeted approach than corticosteroids and thiopurines[71]

There was one case of 1 child whose White Blood Cell (WBC) count started near the bottom of the reference range, and it fluctuated above and below that value during the study, finally ending with a level slightly below the reference range, but without neutropenia or lymphocytopenia