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Description

Mechanisms of desensitization share common features (phosphorylation, accessory proteins involvement such as arrestin, importance of endocytosis and receptor trafficking) and will dependent not only on agonist (biased agonism) but also on time exposure, cell system and receptor

The DNA compositions will generally include a coding region which encodes a polypeptide comprising an amino acid sequence substantially homologous to the amino acid sequence of a PfEMPl protein