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Further, the study may not have adequately considered differences in response to microneedle patches in different individuals (e.g., based on age, sex, and health status)

The most critical class of ligands for innate immune receptors consists of nucleic acids: exogenous DNA, RNA released during viral infection, and double-stranded RNA (dsRNA), which serves as an intermediate in viral RNA-dependent replication [211]

Coinhibitory pathways such as PD-1, CTLA-4 and Tim-3 have been proved to be upregulated in chronic viral hepatitis and critical in hepatic tolerance, contributing to the failure of T-cell response to hepatic pathogens such as HBV, which can be regarded as novel indicators of T-cell immune function in patients with chronic HBV infection

The most frequent offenders are (in this order) wheat, dairy, eggs, and corn