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Efficacy was assessed among all randomized participants regardless of treatment discontinuation or rescue intervention

SIRT1 is downregulated by autophagy in senescence and ageing

Significance was determined using an adjusted p-value threshold of 0.1

3 Application of personalized nursing in CVDs Personalized medical care not only enhances patient health by facilitating precise diagnosis, prevention, and treatment, but also can be tailored based on individual characteristics, contexts, backgrounds, and environments to support self-management and independent living (129, 130)