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Furthermore, the enrichment of glutathione metabolism and nicotinate/nicotinamide metabolism suggests adaptive responses to oxidative and metabolic stress induced by DHODH inhibition

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Therefore, in the past decade, especially under the promotion of nanotechnology, nanodrugs aimed at depleting GSH or inhibiting GSH biosynthesis have been proposed to improve the effect of tumor treatment and reduce the drug resistance to chemotherapy [10, 13]