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Lead, mercury, and other metals can deactivate paraoxonase and other antioxidant enzymes, also contributing to increased free radicals and oxidative stress (1, 31, 32)

Effects of ketogenic diet on neuroinflammation in neurodegenerative diseases

J Clin Endocrinol Metab 45:747754 Schwertheim S, Wein F, Lennartz K, Worm K, Schmid KW, Sheu-Grabellus SY (2017) Erratum to: Curcumin induces G2/M arrest, apoptosis, NF-kappaB inhibition, and expression of differentiation genes in thyroid carcinoma cells