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Using XGBoost, multiple models were trained with seven features - Age, Sex, BMI, AST, ALT, Platelet Count (PLT), and Hemoglobin A1c (HbA1c) - expanding upon those used by FIB-4

ER stress is a typical trait in DbCM, and a recent study demonstrated that induction of ER stress by thapsigargin treatment in non-diabetic mice impairs mitochondrial respiration, may induce mPTP opening, and increases mitochondrial oxidative stress [137]

Hropot M, Juretschke HP, Langer KH, Schwark JR (2001) S3226, a novel NHE3 inhibitor, attenuates ischemia-induced acute renal failure in rats

Here, using multidrug resistance protein 1 (MRP1) activity as an example, we demonstrate that LDEs mediate altered protein function during ferroptosis