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Butyrate as a PPARs Agonist Butyrate is known to be a pleiotropic molecule that as well as binding to FFARs, also has the ability to bind peroxisome proliferator-activated receptors (PPARs) ( in vitro and in vivo , which is associated with upregulation of anti-angiogenic VEGF ( On the other hand, SB may activate AMP kinase (AMPK), which result in upregulation of PPAR coactivator (PGC)-1, PPAR and ( The Effects of Butyrate on CVD Butyrate and Atherosclerosis An increasing number of studies have found that butyrate can exert protective effects in atherosclerosis

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Severe reactions are rare but can occur