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Inflammatory molecules produced by meniscus and synovium in early and end-stage osteoarthritis: a coculture study

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Neurotoxicology 23:367374 Kim JS, Kim J-M, Jeong-Ja O, Jeon BS (2010) Inhibition of inducible nitric oxide synthase expression and cell death by ()-epigallocatechin-3-gallate, a green tea catechin, in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine mouse model of Parkinsons disease

Hydrophobic residues (such as Leu and Ala) cover the surface of the active cavity, which reduces the hydrophobic complementarity between the enzyme and the substrate, and further inhibits the catalytic efficiency (Hu et al., 2022b)