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Mood and microbes: gut to brain communication in depression

Postmortem analyses have confirmed astrocyte activation in the substantia nigra of PD patients, accompanied by elevated pro-inflammatory cytokines [tumor necrosis factor- (TNF-), IL-1, transforming growth factor-, and IL-6], ROS, NO, pro-apoptotic proteins, and T-cell infiltration

Cancer (2019) 125(21):3790800

There is, however, evidence to support that dogs with cropped ears are perceived differently than dogs with natural ears, which is likely playing a role in adoption rates of dogs with cropped ears