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Options at plateau include maintaining the current dose to prevent regain (the STEP 4 trial showed rapid weight regain after discontinuation), adding structured exercise to increase energy expenditure, reviewing dietary quality rather than just quantity, and in some cases, considering a temporary dose increase if prescribed by a provider

Severe anaemia significantly increases perioperative risk

Maintaining a training regimen while on Retatrutide preserves muscle mass and improves body composition outcomes

In addition, some promising targets in LSCs have recently been identified, including Sonic Hedgehog (SHH) and BCL-2, which are highly expressed in AML cells