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Until consolidated evidence emerges, clinicians should approach ozone therapy with circumspection, calibrating its use based on individual patient needs and clinical contexts

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Small molecules, peptides, and gene therapies : designed to intervene in disease pathways (oxidative stress, mitochondrial dysfunction, protein homeostasis) Early detection & biomarker approaches : using imaging (PET scans), cerebrospinal fluid biomarkers, and (more recently) blood-based biomarkers to detect Alzheimers before symptoms arise and enable earlier intervention