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The complexity of even simple living organisms means that it is challenging to work out which compounds, or even class of compound, affect ice nucleation

Treatment for tendonitis may include rest, ice or heat therapy, anti-inflammatory medications, and physical therapy to improve range of motion and strengthen the affected tendon

Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

Whilst this study primarily focused on metformin-mediated effects in tumour cells, increasing evidence implicates a role for metformin in the modulation of immune cells, with metformin demonstrated to modulate macrophage polarisation (71) and the infiltration and function of T-cells (72, 73)