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Moderate-mutant tumor cells establish an immunosuppressive tumor microenvironment through upregulation of S100A8/A9 signaling To determine whether the immunosuppressive microenvironment is driven by tumor cellintrinsic factors, we analyzed the immune profiling data from tumors formed by transplanted moderate-mutant primary tumor cells or mutant 4T1 cells, which showed a significant increase in MDSCs and a concomitant decrease in CD8 + T cells (Extended Data Fig