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Why this is important: Reduced blood flow to the feet If a Vitamin B12 deficiency is causing a reduction or interrupted blood supply to the feet, you may experience very cold feet without reprieve, changes in skin colour (feet may appear white or purple), development of chilblains, muscle cramping and numbness

Patch test prior to first use

Springer, Berlin, pp 231258 Herrera K, Cahoon RE, Kumaran S, Jez JM (2007) Reaction mechanism of glutathione synthetase from Arabidopsis thaliana site-directed mutagenesis of active residues

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