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This criteria identified methylcobalamin, acetyl-L-carnitine, and vitamin E, though upon review of the literature, randomized trials of vitamin E in high and regular dosing did not meet primary endpoints [104,105,106], and is associated with increased risk of hemorrhage [107] and slight increased risk of prostate cancer [108], and is not recommended by consensus guidelines [98]

Cell Mol Life Sci 63:30613071

Nanomedicine targeting mitochondria is the key to solve this problem

Cell proliferation and interleukin-6-type cytokine signaling are implicated by gene expression responses in early optic nerve head injury in rat glaucoma