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pluvialis derived AST as a "GRAS" (Generally recognized as safe) in 1999 and can be considered as a nutraceutical compound for consumptions [43]

Arch Gen Psychiatry 66 : 2232

doi:10.1007/s10867-009-9157-9 [15] Puri BK, Jakeman PM, Agour M, Gunatilake KDR, Fernando KAC, Gurusinghe AI, Treasaden IH, Waldman AD, and Gishen P

276 While AD has genetic causes, notably the apolipoprotein E4 (ApoE4) allele, which promotes the accumulation of A plaques through the MAPK signaling pathway, 277 the majority of cases are sporadic and strongly age-associated