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demonstrated CD38 KO, CD38 inhibitors treatment, or adeno-associated virus (AAV)-mediated endothelial CD38 knockdown can reduce blood pressure and improve vascular dysfunction in AngII-induced hypertensive mice [45]

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These studies show increased NAD+ metabolites and report potential improvements in fatigue, sleep, and mood

By adopting a dual-pathway strategytargeting both pain relief and inflammation reductionwe observed significant improvements in joint function during clinical trials involving over 5,000 participants