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In therapeutic and commercial applications of exogenous mRNA these modifications (Figure 3) are made in order to increase translation initiation, improve expression and reduce immunogenicity [ FIGURE 3 It is recorded that innate immune system differentiates self-originating mRNA from IVT mRNA triggering immune responses via pattern recognition receptors (PRRs)

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[DOI] [PubMed] [Google Scholar] 76.Christen W.G., Cook N.R., Van Denburgh M., Zaharris E., Albert C.M., Manson J.E