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Structural features of Cagri-bound active CTR complexes Previous structural analysis of CTR-Gs bound to rAmy revealed that the receptor complex was dynamic, adopting distinct states where the receptor was resolved into two major conformations, a bypass (55%, PDB: 7TYL) and CT-like (45%, PDB: 7TYI) conformation 15

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Immediate sample processing (centrifugation, plasma separation, freezing at 80C) is essential to prevent ex vivo peptide degradation

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