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doi: 10.1016/j.tcb.2010.03.004 177 RaghowRYellaturuCDengXParkEAElamMB

Typically, the full effectiveness of the drug cannot be felt for a few weeks of use

In addition to the safety communication, FDA is requiring that 1) new warnings about the risk of respiratory depression be added to the prescribing information of the gabapentinoids, and 2) drug manufacturers conduct clinical trials to further evaluate abuse potential of the gabapentinoids, particularly in combination with opioids, because misuse and abuse of these products together is increasing, and co-use may increase the risk of respiratory depression