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The main disadvantage of the ibuprofen therapy is related to its narrow therapeutic window, which results in a particular carefulness in drug dosage

Sengupta, S., Peterson, T

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Apart from these two types of FINs, other methods or compounds can also induce ferroptosis (Figure 1): L-buthionine sulfoximine (BSO) suppresses glutamate-cycteine ligase (GCL) and induces GSH depletion (Seiler et al., 2008