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12,15-17 Additional literature suggests an associated increase in opioid receptor expression in relation to this opioid rebound effect

As it was hypothesized [11], ozone does not penetrate the cells but oxidizes available antioxidants and reacts instantaneously with surfactant's polyunsaturated fatty acids (PUFA) present at the interface to form Reactive Oxygen Species (ROS), such as hydrogen peroxide and a mixture of heterogenous LOPs including lipoperoxyl radicals, hydroperoxides, malonyldialdeyde, isoprostanes, the ozonide and alkenals, particularly 4-HNE [2729]