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Metabolic reprogramming driven by oncogenes allows cancer cells to maintain deregulated cell proliferation, withstand metabolic challenges that are associated with diminished oxygen and nutrients, maintain a dedifferentiated state through alterations in global patterns of gene expression, and corrupt the surrounding microenvironment to actively facilitate tumor growth and dissemination 16,17,18

The results showed that NAC supplementation reduced the total dose and duration of gonadotropins required for OI in women with PCOS

Due to their similar structures, both hCG and LH bind to the same LHCGR receptor on Leydig cells, but hCG does so with greater affinity, preferentially inducing cAMP and increasing intracellular Ca, upregulating genes that code steroidogenic enzymes

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