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Systemic side effects are extremely uncommon when therapy is supervised properly

[2] Use of estradiol cypionate injection is contraindicated in individuals with undiagnosed abnormal vaginal bleeding, known or suspected breast cancer or other estrogen-dependent neoplasia, active or prior venous thromboembolism, recent arterial thrombo-occlusive disease such as stroke or myocardial infarction, severe hepatic impairment, a history of hypersensitivity to estradiol or any excipients, and in those who are or may become pregnant

Simpsons colleague at Opt Health, agrees: Theyre mimicking what your body already does but with more specificity

Conditions such as pre-eclampsia are not only risks to be managed for nine months