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Findings from this study may have health implications for those with ischemic conditions such as peripheral vascular disease and ischemic heart disease, as increased NOx may allow for enhanced blood flow, in particular during times of physical stress

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One study revealed that mitochondrial AC deficiency and fatty acid metabolism disorders were not related to fatigue in patients with MS (53)

Autonomic dysfunction including bladder, bowel and sexual dysfunction, and cardiovascular dysautonomia, usually precedes motor symptoms, but become more relevant with disease progression 160