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doi: 10.1016/j.chembiol.2023.10.011 174 ChenHZhongYSangWWangCLuHLaiPet al

2013;34:34783490a

A double-blind, placebo-controlled trial on CB4211, which is an analog (synthetic version) of MOTS-c, found the compound to be "safe and well tolerated" under a single and multiple ascending dose protocol in adult humans

Uric acid has been shown to prevent glutamate-induced cell death in vitro and to inhibit ROS and RNS to reduce infarct size and improve prognosis in rodents after transient or permanent cerebral ischemia (Squadrito et al., 2000