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Interestingly, chronic oral administration of rotenone to rodents in vivo induces many key features of PD, including selectively and progressive nigrostriatal DA neurodegeneration, abnormal behaviours (not seen in the MPTP mouse model) and formation of Lewy bodies (not seen in either the MPTP or 6-OHDA mouse model) 30

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A closer examination of circulating metabolites contributes to our understanding of the pathophysiology and may potentially provide markers of PsA disease: integrating this knowledge with current precision medicine efforts, clinicians could be guided in developing personalized interventions (for example, with aminoacidic monitoring and/or supplementation), based on the patients metabolic profile