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doi: 10.1016/j.cmet.2012.04.001 386 RuanHPownallHJ

Many who opted for pharmaceutical solutions have been there, done that and found the results to be lacking, or contributed to debilitating consequences

2, rational engineering of nanomedicines that precisely target glucose metabolism, which includes glucose supply, glucose depletion, modulation of glycolytic enzymes, and simultaneously blocking oxidative phosphorylation and glycolysis, represents a promising therapeutic paradigm to disrupt tumor bioenergetics and halt malignant progression [55, 56]

5.2 Multiple sclerosis Multiple sclerosis is a chronic inflammatory demyelinating disease of the CNS (242)