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EMT is characterized by the downregulation of cell-cell adhesion molecules, including E-cadherin, and the upregulation of mesenchymal markers, such as SMA, fibroblast-specific protein 1 (FSP1), fibronectin, collagen, and vimentin (70)

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This triggers collagen synthesis , attracts immune cells, promotes blood vessel formation, and activates dozens of genes involved in tissue repair

So even though they are no longer formally restricted by Category 2, the affirmative basis to compound them at scale still doesnt exist