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Spread from injection site: Postmarketing reports indicate that the effects of Botox and all botulinum toxin products may spread from the area of injection to produce symptoms consistent with botulinum toxin effects In unapproved uses, including spasticity in children, and in approved indications, cases of spread of effect have been reported at doses comparable to those used to treat cervical dystonia and upper limb spasticity and at lower doses. -Botox boxed safety sheet Literature on use and benefits The Use of Botulinum Toxin for Treatment of Spasticity: A review of how Botox reduces spasticity but may have variable effects on voluntary movement, and considerations on improving efficacy

Role for -arrestin in mediating paradoxical 2AR and PAR2 signaling in asthma

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