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This process is known as chaperone-mediated autophagy, abbreviated as CMA [63] During starvation, CMA is enhanced and exhibits enrichment with an increase in both cytoplasmic ATGL levels and macroautophagy-associated proteins [64], possibly indicating that CMA-mediated degradation of LDs requires the coordination of lipolysis and macroautophagy

There is some evidence that the diabetes drug metformin (Glucophage) may reduce vitamin B12 absorption when used for several years

Yildirim M, Inaloz HS, Baysal V, Delibas N

In HD patient-derived cells, a downregulation of DNA repair genes ( APEX1 , BRCA1 , RPA1 , and RPA3 ), which are involved in mismatch and loop-out repair pathways was observed