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McGill and Jaeschke 2014) and to biomarkers that are amenable to measurement within biofluids that are easy to obtain in humans (e.g., blood and urine)

Consequently, mTOR impairment resulted in an increase in autophagy

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In sepsis, LPS binds to the TLR4-MD2-CD14 receptor on lung cells, activates the MyD88-dependent signaling pathway, promotes the ubiquitination of TRAF6 and activates the TAK1/IKK/NF-B pathway, inducing the release of pro-inflammatory factors such as TNF- and IL-1 (162, 163)