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Adopting healthy lifestyles such as ones already described in previous paragraphs can have a substantial impact on overall health and longevity, even for individuals that have some adverse genetic predispositions (Wang et al., 2023)

In PD, the M1 phenotype may be induced by -syn aggregates, signaling through Toll-like receptors (TLR), releasing cytokines and neurotoxic molecules that promote cytotoxic responses, leading to persistent neuroinflammation (Li et al., 2021a)

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Tests on humans include a pilot study, which recruited 2 participants who received BPC-157 intravenously, and a Phase I human trial, which involved 47 participants, but for which the results were not published