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Description

Br J Pharmacol (2011) 162(1):28694

& Dubrow, R

Journal Of Pharmacology And Experimental Therapeutics, 301(2), 543-550

Combining pulldown experiments and functional assays to identify senolytic targets To identify the targets responsible for their senolytic activity, we synthesized two alkynylated derivatives of each compound, which we used to perform target identification in competitive, protein-directed activity-based protein profiling (ABPP) experiments (Fig