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Marseglia, L., DAngelo, G., Manti, S., Reiter, R

It reveals that selective ubiquitin-proteasomal degradation of PHGDH may be a more viable therapeutic strategy compared to PHGDH enzyme inhibitors

Their results revealed that decreasing NNMT expression in primary hepatocytes led to a reduction in the expression of phosphoenolpyruvate carboxykinase 1 (Pck1) and glucose-6-phosphatase (G6pc), resulting in decreased glucose output