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doi: 10.1186/s13287-025-04511-2 179 FangXGaoFZhengLXueF-SZhuTZhengX

Lipid peroxidation can also occur in other cell death types, which depend on different ultimate effectors

Furthermore, we found that APR-246, known for reducing intracellular GSH levels and reactivating mutant p53, induces oxidative stress and accelerates cell death in SNF2L-deficient cells

Genetic variants in antioxidant enzymes and mitochondrial function genes may influence individual glutathione levels and oxidative stress susceptibility