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In situation of an increase in hepatocellular cytosolic Cu, ATP7B localizes to an acidified vesicular compartment near the canalicular membrane to accumulate Cu 2+ for subsequent excretion into bile ( Figure 1 ) (27-30)

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Genet Med 21(12):28152822 Kubo T, Kitaoka H (2023) Genetic testing for cardiomyopathy in Japan 2022: current status and issues of precision medicine