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Pharmacological or genetic activation of PINK1 stabilization and Parkin recruitment enhances mitochondrial turnover and reduces cytosolic mtDNA levels [60]

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Strategies targeting metabolic vulnerabilities will not only eliminate backup systems to prevent ferroptosis [49] , but also receive considerable attention in cancer therapeutics [54]

Wang M , Locke FL, Munoz J, Goy A, Holmes HE, Siddiqi T, Flinn I, McSweeney PA, Reagan PM, Hill BT, Jacobson CA, Rizzieri DA, Heffner LT, Jaglowski SM, Miklos DB, Shaughnessy P, Unabia S, Rossi JM, Jiang Y, Jain RK