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207 In addition, a large study that followed 2,968 subjects with cardiovascular disease for a median of almost 10 years found lower B 6 levels and higher homocysteine levels were each associated with increased mortality, higher levels of oxidative stress and inflammatory markers, and shorter telomere length for age, suggesting accelerated biological aging

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Consistent with previous reports, the MCD diet significantly downregulated hepatic SIRT1 expression