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There was variation in the painful CIPN baselines across dose groups for both sexes (Figure 3 top, PWT gram data) as well as an observable and statistically significant increase in PWTs at the 3 mg/kg dose for both male and female rats (Figure 3 bottom, normalized percent scores)

Special Needs Plans United Healthcare Options (PPO) TriWest Healthcare Alliance CareFirst EPO CIGNA Indemnity Choice POS CareFirst MedStar PPO Education Board Certification: American Board of Radiology, Radiation Oncology Residency: Duke University School of Medicine (2015) Medical School: Pennsylvania State University (2010)

The first step, catalyzed by glutamate-cysteine ligase (GCL), is rate-limiting and regulated by GSH (competitive inhibitor) and by cysteine availability (Lu, 2013)

Upregulated bone morphogenetic protein 5 enhances proliferation and epithelial-mesenchymal transition process in benign prostatic hyperplasia via BMP/Smad signaling pathway