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The fact that a productive structure could not be solved may indicate that the active state is transient and, thus, sparsely populated 19,20

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In a documented case of severe pustular psoriasis that did not respond to steroids, dapathon, and methotrexate, clinical improvement was observed within 2 weeks after initiation of Lactobacillus sporogenes supplementation three times a day, and almost complete resolution was observed at 4 weeks (Sikora et al., 2019)

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