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Am J Med 130:124134 Addolorato G, Mirijello A, Barrio P, Gual A (2016) Treatment of alcohol use disorders in patients with alcoholic liver disease

in 1972

Sato H, Goto W, Yamamura J, Kurokawa M, Kageyama S, Takahara T, et al

Numerous toxicity studies have been done to assess the safety of MSM and doses up to 4,845.6 mg per day (4.8 grams) appear to be safe ( However, some people may experience mild reactions if they are sensitive to MSM, such as stomach issues like nausea, bloating and diarrhea