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Tuder RM, Zhen L, Cho CY, Taraseviciene-Stewart L, Kasahara Y, Salvemini D, Voelkel NF, Flores SC (2003) Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade

However, isoliquiritigenin not only inhibits VEGFR activity by directly interacting with the ATP-binding site of VEGFR, but also blocks VEGF expression via promoting HIF-1 the proteasomal degradation of HIF-1 [231]