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Kibugu J, Munga L, Mburu D, Maloba F, Auma JE, Grace D, et al

10.1007/s12649-020-01126-x 244

Int J Polym Sci

In PTC and ATC cell lines, aurora-A, a member of the aurora serine/threonine kinase family, induces glycolysis by activating 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), and the inhibition of aurora-A with its selective inhibitor, alisertib, has been shown to improve the efficacy of sorafenib in both PTC and ATC cells [77]