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They also promote NO production, which is required for cell death induction ( Arabidopsis PCD by promoting MPK6-mediated caspase-3-like activation (Ye et al., 2013)

[7] All potential female patients are screened and counseled on this point, and effective contraception is recommended for those undergoing NAD+ therapy if applicable

However, the relatively modest increase in ATP production (~22%) compared to the doubling of proton leak suggests that part of the respiratory activity may be uncoupled from ATP synthesis at the end of the study

10.1016/j.molmet.2021.101195 7 BabaultN.Allali-HassaniA.LiF.FanJ.YueA.JuK.et al (2018)