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And though no ongoing trials target specific genes identified in screening studies, several clinical investigations implicate genetic dependencies identified in genetic screens

By contextualizing OSC activity alongside current last-line antibiotic regimens (e.g., -lactam/-lactamase inhibitor combinations) and recent outcome data from multidrug-resistant Gram-negative infections, we underscore that incremental antibiotic optimization alone continues to leave substantial residual mortality and incomplete microbiological clearance, thereby strengthening the rationale for adjunctive, dual-action strategies

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Thus, to maximize therapeutic outcomes, novel designs are required to advance the facile integration of different therapeutics onto platelet carriers, progressively improve both binding and penetration in atherosclerotic lesions, and ensure on-demand drug delivery to plaque macrophages