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6 , 9 Patient safety is a recognised concern in primary care 10 especially for marginalised groups such as people with vitamin B12 deficiency

Most side effects are transient and resolve within the first weeks of treatment

Metastatic breast cancer, not the primary tumor, is responsible for more than 90% cancer-related deaths (3)

Consequently, inhibited PHGDH combined with suppressed pyruvate kinase (PK) M2 can inhibit cancer cell proliferation and induce G2/M phase arrest in non-small cell lung cancer A549 cells (Wang et al., 2023)