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2022;45(Suppl 1):A58-A59

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Nevertheless, primary cancers with similar tumour-initiating mutations and other early mutations can eventually progress towards vastly different metastatic phenotypes, specific transcriptional programmes correlate with poor patient prognosis and metastasis in several, if not all, tumour types, and stable highly metastatic cancer clones with distinct gene expression programmes can be isolated from multiple different human- and mouse-derived experimental cancer models